CH.0 / REFERENCES CHANNEL
every citation, with a link
The eighteen primary references behind this site, color-coded by component channel where the citation maps to a single peptide.
Citation index
The references below are numbered to match the inline [N] markers used across the site. Channel labels (R / G / B) indicate which GLOW component the citation primarily addresses; M denotes a methodological or biochemical source not tied to a single component. Where a peer-reviewed DOI is available it is included; otherwise the PubMed or PMC identifier is given. All linked sources are publisher pages or PubMed Central full-text records.
Readers interested in the broader thymosin beta-4 program (parent of TB-500) or the full BPC-157 development history (including the unpublished PL-14736 Phase II) should follow the linked papers' own reference lists for the deeper trail.
Citation notes by channel
Channel R / GHK-Cu references [1][2][3][4][5][17] cover the 1994 Mulder diabetic-ulcer trial (the most-cited controlled human result for GHK-Cu), the Pickart 2014 transcriptomic Connectivity Map paper, two mouse lung-injury and fibrosis studies, the hair-follicle ex vivo work, and a 2025 liposomal-formulation review.
Channel G / BPC-157 references [6][7][8][9][10][16][18] cover the tendon-fibroblast growth-hormone-receptor work, the Achilles tendon transection model, the Src-Caveolin-1-eNOS vasomotor pathway, the 2025 McGuire narrative review of human evidence, two Sikiric mechanistic syntheses, and the Pliva PL-14736 paper that anchors the unpublished Phase II trial.
Channel B / TB-500 references [11][12][13][14][15] cover the biochemical basis for thymosin beta-4 as the major intracellular G-actin sequestering peptide, the 2023 Phase III ophthalmic trial of RGN-259 in neurotrophic keratopathy, the 2004 Nature cardiac-regeneration paper, the 2010 rat embolic-stroke model, and the 2011 myoblast-chemoattractant study. The 2024 engineered tandem-Tβ4 work is also referenced where the corneal repair section discusses recent formulation progress.
- Mulder GD, Patt LM, Sanders L, Rosenstock J, Altman MI, Hanley ME, Duncan GW. Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-L-histidyl-L-lysine copper. Wound Repair and Regeneration. 1994;2(4):259-269. ↗
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK and DNA: Resetting the Human Genome to Health. BioMed Research International. 2014;2014:151479. ↗
- Park JR, Lee H, Kim SI, Yang SR. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. 2016;7(36):58405-58417. ↗
- Zhang Q, Yan L, Lu J, Zhou X. Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways. Life Sciences. 2020;241:117117. ↗
- Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC, Cho KH, Kim KH. The effect of tripeptide-copper complex on human hair growth in vitro. Archives of Pharmacal Research. 2007;30(7):834-839. ↗
- Chang CH, Tsai WC, Hsu YH, Pang JHS. Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts. Molecules. 2014;19(11):19066-19077. ↗
- Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHS. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology. 2011;110(3):774-780. ↗
- Hsieh MJ, Lee CH, Chueh HY, Chang GJ, Huang HY, Lin Y, Pang JHS. Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Scientific Reports. 2020;10:17078. ↗
- McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM. Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing. Current Reviews in Musculoskeletal Medicine. 2025;18(4). ↗
- Sikiric P, Skrtic A, Gojkovic S, et al. Stable Gastric Pentadecapeptide BPC 157 May Recover Brain-Gut Axis and Gut-Brain Axis Function. Pharmaceuticals. 2023;16(5):676. ↗
- Sosne G, Qiu P, Kurpakus-Wheater M. Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent. Clinical Ophthalmology. 2009;3:415-423. ↗
- Sosne G, Dunn SP, Kim C. 0.1% RGN-259 (Thymosin β4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial. International Journal of Molecular Sciences. 2023;24(1):554. ↗
- Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-472. ↗
- Morris DC, Chopp M, Zhang L, Lu M, Zhang ZG. Thymosin β4 improves functional neurological outcome in a rat model of embolic stroke. Neuroscience. 2010;169(2):674-682. ↗
- Tokura Y, Nakayama Y, Fukada SI, Nara N, Yamamoto H, Matsuda R, Hara T. Muscle injury-induced thymosin β4 acts as a chemoattractant for myoblasts. Journal of Biochemistry. 2011;149(1):43-48. ↗
- Sikiric P, Seiwerth S, Brcic L, et al. Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL 14736), is effective in the healing of colocutaneous fistulas in rats. Journal of Pharmacological Sciences. 2008;108(1):7-17. (Cited here as the anchor paper for the unpublished PL-14736 Phase II program and for the absence of any peer-reviewed full-GLOW combination study.) ↗
- Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes? Pharmaceutics. 2025;17(1):52. ↗
- Sikiric P, et al. BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide's Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions. Pharmaceuticals. 2025;18(10):1450. ↗
- Mendias CL, Awan TM. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. Sports Medicine. 2026. ↗